HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (S)-4-benzyl-6-methylpiperazin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 60208241 | HCID 60208241 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (S)-4-benzyl-6-methylpiperazin-2-one | HCID 45096892 | — |
Reaction Steps
Ester (2) was stirred in a 50:50 solution of TFA:CH2Cl2 for 1 hour. The solvent was then removed, and the residue was redissolved in methylene chloride and washed with a saturated solution of Na2CO3. The organic layer was then separated and dried over MgSO4 giving desired piperazine compound (3) as a white solid (87%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07368453B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-b239cffa43ba4f3499233235404563f0 |
| Source note | uspto-grants-2008_05 |