(2S,3S)-3-methylpyrrolidine-2-carboxylic Acid → HCID 57463460, compound

HRID 2221006Notes

Reaction equation

HRID 2221006 reaction equation
[CH3:1][C@H:2]1[CH2:6][CH2:5][NH:4][C@@H:3]1[C:7](O)=[O:8].[ClH:10].O[C@H]1CCN[C@@H]1C(OCC)=O>>[ClH:10].[CH3:1][C@H:2]1[CH2:6][CH2:5][NH:4][C@@H:3]1[CH2:7][OH:8]

Participants

3

Reactant 2

HCID 2724879(2S,3S)-3-methylpyrrolidine-2-carboxylic AcidHCID 69063309HCID 69063309, compound

Product 1

HCID 57463460HCID 57463460, compound

Procedure

The title compound was prepared from (3S)-3-methyl-L-proline, using the methods used to prepare ethyl(3S)-3-hydroxy-L-prolinate hydrochloride. 1H NMR (400 MHz, DMSO-D6) δ ppm 1.1 (d, J=6.8 Hz, 3 H) 1.2 (t, J=6.8 Hz, 3 H) 1.6 (m, 1 H) 2.1 (m, 1 H) 2.3 (m, 1 H) 3.2 (m, 2 H) 3.8 (m, 1 H) 4.2 (m, 2 H) 4.7 (m, 1 H) 9.0 (s, 1 H) 10.4 (s, 1 H).

Sources & evidence

ORD record
ord-1465d0dc407d4c838fe358df4171ce39
Source dataset
uspto-grants-2008_05
Patent number
US07368453B2

Reaction notes

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