Sodium Hydroxide → sodium;(E)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoate

Participants

Reaction Conditions

Reaction Steps

A 100 ml round bottom flask was loaded with fluvastatin tert-butyl ester (2.0 g, 4.28 mmole), EtOH (20 ml) and NaOH (0.18 g). The mixture was heated to 50° C. and stirred for 2.25 h then cooled to room temperature and the EtOH was evaporated. The volume of the water was completed to 8 vol. and the mixture was extracted with EtOAc (2×20 ml). The aqua solution was evaporated to obtain 4.22 g and ACN (30 ml) was added. The solution was stirred at room temperature over the weekend. The product was isolated by filtration under nitrogen, washed with ACN (20 ml) and dried at 40° C. in a vacuum oven for 24 h to obtain 1.15 g (62%) of fluvastatin sodium crystal form LXXIX.

Provenance & Evidence