Lawesson's reagent → 2-Thioxo-[1,4']bipiperidinyl-1'-carboxylic acid benzyl ester

Participants

Reaction Steps

2-Oxo-[1,4′]bipiperidinyl-1′-carboxylic acid benzyl ester (3.1 g) in tetrahydrofuran (10 mL) was added to a suspension of Lawesson's Reagent (1.98 g) in tetrahydrofuran (40 mL). After 20 minutes the reaction was concentrated and the resulting gum was subjected to chromatography with methylene chloride: ether (gradient 10:1, 5:1) as eluent. The title compound was obtained as a white foam (2.9 g). Rf=0.42 in methylene chloride:ether (10:1). MS: m/z=333 (M+H).

Provenance & Evidence