(Z)-Methyl 2-(benzyloxycarbonylamino)-3-(2-(tert-butoxycarbonyl amino)-5-phenylpyridin-3-yl)acrylate → Methyl 2-(benzyloxycarbonylamino)-3-(2-(tert-butoxycarbonyl amino)-5-phenylpyridin-3-yl)propanoate

Participants

Reaction Steps

A suspension of 1E (560 mg, 1.11 mmol) and 5% wt. platinium on activated carbon (500 mg) in THF (90 mL) and MeOH (90 mL) was stirred at RT under H2 at 80 psi for 2 days. After this time, no starting material was detected by LC-MS. The reaction mixture was filtered and the filtrate was concentrated. The residue was purified by silica gel (40 g) column chromatography eluting with a gradient of EtOAc (0-60%) in hexane to give the title compound as a foam (420 mg, 75%). LC/MS (method A): retention time=3.24 min, (M+H)+=506.

Provenance & Evidence