Benzyl 1-benzyl-2-oxo-6-phenyl-1,2,3,4-tetrahydro-1,7-naphthyridin-3-ylcarbamate → 3-Amino-1-benzyl-6-phenyl-3,4-dihydro-1,7-naphthyridin-2(1H)-one

Participants

Reaction Steps

To a solution of 3G (300 mg, 0.65 mmol) in THF (80 mL) and MeOH (80 niL) at RT was added palladium 5% wt. on activated carbon (150 mg). The reaction mixture was stirred under a hydrogen balloon for lh. The reaction was filtered and the filtrate concentrated to give the title compound as a foam (144 mg, 91%). LC/MS (method A): retention time=2.37 min, (M+H)+=330.

Provenance & Evidence