Hydrazine → HCID 178422629, compound

Participants

Reaction Steps

To a stirred solution of compound 5A, (4.48 g, 23.6 mmol) in 50 mL of methanol at 35° C. under argon was added hydrazine (0.75 mL, 35.3 mmol) over 5 min The reaction mixture was then heated to reflux under argon for 2 h, as a precipitate formed. The reaction mixture was then cooled and evaporated under reduced pressure. The solid residue was slurried in isopropanol, filtered and air-dried to give 4-methyl-6-phenylpyridazin-3-ol (2.66 gm, 61%) as a yellow solid. MS [M+H]+: found 187.

Provenance & Evidence