Cysteamine → S-Tritylcysteamine

Participants

Reaction Steps

To a stirred solution of cysteamine (Fluka, 3.85 g, 50.0 mmol) in trifluoroacetic acid (TFA) (50 ml) was added triphenylmethanol (13.0 g, 50.0 mmol). The mixture was stirred at room temperature for 30 min and concentrated. To the residue was added ether (250 ml). Precipitated material was filtered off and washed with ether. The TFA-salt was partitioned between 1 M aqueous KOH solution (150 ml) and ether (150 ml). The phases were separated and the ether phase was dried (MgSO4). The solution was filtered and concentrated and the product was crystallised from ether/n-hexane, giving 9.20 g (58%) of white solid.

Provenance & Evidence