Ammonia → HCID 68704306, compound

Participants

Reaction Steps

A solution of methyl 4,5-dihydro-1H-pyrrolo[2,3-f]isoquinoline-2-carboxylate L1 (0.44 mmol) in DMF (5 mL), MeOH (5 ml) and 30% aq NH3 (10 mL) was heated at 80° C. in a close vessel for 8 h. The solvent was evaporated, the residue was dissolved with DCM and washed with water. The organic layer was dried (Na2SO4) and concentrated to provide, after trituration with diethylether, the title compound (50% yield). ESI (+) MS: m/z 214 (MH+). 1H NMR: 2.69 (m, 2H), 2.84 (m, 2H), 6.72 (d, J=2.19, 1H), 7.08 (bs, 1H), 7.74 (d, J=5.12, 1H), 8.33-8.44 (2m, 2H), 12.01 (s, 1H).

Provenance & Evidence