Formamide → 6-Iodoquinazolin-4-one

Participants

Reaction Steps

Reflux 2-amino-5-iodo-benzoic acid (Aldrich; 10 g, 38 mmol) in formamide (30 mL) at 120° C. for 18 h. Upon cooling to room temperature, the product is crystallized from the solvent. The product is collected via filtration and the resulting crystals are washed with ether providing the desired 9.2 g (89%) of the titled compound as a pale solid. MS ES+ m/e 273.0 (M+1).

Provenance & Evidence