Hydrochloric Acid → HCID 58916337, compound

Participants

Reaction Steps

Cool a solution of 2-{7-[2-[6-methyl-(pyridin-2-yl)]-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]-quinoxalin-2-yloxy}-ethanol (0.5 g, 1.3 mmol) and diisopropylamine (0.5 ml) in dry dichloromethane (10 mL) to −30° C. Add methanesulfonylchloride (0.5 ml) dropwise to the solution and stir the resulting mixture for 30 min while allowing the reaction mixture to warm to room temperature. Add 5 N hydrochloric acid (0.2 mL) and pyridine (1 mL) to the mixture and heat at 80° C. for 3 h. Dilute the reaction mixture with 1:1 chloroform/isopropyl alcohol and wash the solution with saturated sodium chloride solution. Dry the organic layer (sodium sulfate), filter, and evaporate the solvents. Purify the residue by silica gel chromatography (dichloromethane to 1:1 dichloromethane/methanol) to give 274 mg (68%) of the titled compound. MS ES+ 407 (M+1).

Provenance & Evidence