Pyrrolidine → HCID 66679022, compound

Participants

Reaction Conditions

Reaction Steps

Combine 1-(2-chloro-ethyl)-7-[2-[6-methyl-(pyridin-2-yl)]-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]-1H-quinoxalin-2-one (Preparation 7; 60 mg, 0.15 mmol) and pyrrolidine (0.5 ml) in dioxane (5 mL) in a pressure tube. Seal the tube and heat at 110° C. for 40 min. Dilute the reaction mixture with 1:1 chloroform/isopropyl alcohol and wash the solution with saturated sodium chloride solution. Dry the organic phase (sodium sulfate), filter, and concentrate in vacuo. Purify the residue by silica gel chromatography (dichloromethane to 1:1 dichloromethane/methanol) to give 54 mg (84%) of the titled compound. MS ES+ m/e 441 (M+1).

Provenance & Evidence