Hydrochloric Acid → HCID 86600986, compound

Participants

Reaction Steps

To a solution of 4-{2-[3-benzofuran-2-yl-4-(2-pyrrolidin-1-ylethoxy)but-2-enoyl-amino]ethoxy}benzoic acid methyl ester (90 mg, 0.182 mmol) in THF (1 ml), a solution of hydroxylamine in 50% water (1 ml) and 1N NaOH (0.050 ul) were added. Methanol was added dropwise until a homogeneous solution was obtained and the reaction mixture was stirred overnight at rt. After cooling the mixture at 0° C., 6 N HCl was added until pH 7 was reached. The crude solid was filtered and purified by HPLC to give the title compound (17 mg) as white solid. LC/MS, M+1: 494.3; M−1: 492.2.

Provenance & Evidence