7,8-Dihydroisoquinolin-5(6H)-one--hydrogen chloride (1/1) → HCID 68707913, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 7,8-dihydro-6H-isoquinolin-5-one 8A (13.3 mmol) and pyridinium bromide perbromide (13.3 mmol) were suspended in glacial acetic acid (15 mL), and heated to 100° C. with microwave irradiation for 15 min. The solid formed was filtered to give the title compound as a yellow solid in 83% yield. ESI (+) MS: m/z 227 (MH+). 1H NMR: 2.39-2.62 (m, 2H), 3.00-3.15 (m, 2H), 4.43 (dd, J=12.50, 4.94, 1H), 7.72-7.83 (m, 1H), 8.61-8.74 (m, 1H), 8.75-8.85 (m, 1H).

Provenance & Evidence