Potassium Hydroxide → HCID 10224110, compound

Participants

Reaction Steps

2-{1-Benzyl-4-[4-(trifluoromethyl)phenyl]-1H-indol-3-yl}-2-oxoacetic acid was prepared from ethyl {1-benzyl-4-[4-(trifluoromethyl)phenyl]-1H-indol-3-yl}(oxo)acetate (0.064 g, 0.142 mmol), and potassium hydroxide (0.0471 g, 0.839 mmol) in THF (2.5 mL) and water (2.5 mL) according to the procedure described in Step 4 of Example 5. The title compound was obtained as a light yellow solid (0.0497 g, 89%), mp: 183-184° C. Mass spectrum (+APCI, [M+H]+) m/z 424; 1HNMR (400 MHz, DMSO-d6): δ 13.5-14.0 (br s, 1H), 8.65 (s, 1H), 7.65-7.7 (m, 3H), 7.25-7.45 (m, 8H), 7.2 (dd, 1H, J=7.3 Hz and 0.73 Hz), and 5.65 ppm (s, 2H). Elemental Analysis for C24H16F3NO3.0.20 H2O: Calculated: C, 67.51; H, 3.87; N, 3.28. Found: C, 67.54; H, 3.56; N, 3.17.

Provenance & Evidence