Hydrogen Bromide → HCID 68705832, compound

Participants

Reaction Steps

To stirred, cold (4° C.) 33% HBr in acetic acid (27 mL), cyano-(5-oxo-5,6,7,8-tetrahydro-isoquinolin-6-yl)-acetic acid ethyl ester 8C (7 mmol), dissolved in acetic acid (22 mL) and diethyl ether (22 mL), was added dropwise. The mixture was stirred at rt for 15 h. The yellow precipitate was filtered and repeatedly washed with diethyl ether affording the title product in 89% yield. ESI (+) MS: m/z 322 (MH+). 1H NMR: 1.32 (t, J=7.19, 3H), 3.02-3.33 (m, 4H), 4.17-4.31 (m, 2H), 7.89 (d, J=6.22, 1H), 8.61-8.64 (m, 1H), 8.65-8.70 (m, 1H), 13.49 (bs, 1H).

Provenance & Evidence