Lithium Chloride → HCID 68707167, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-bromo-4,5-dihydro-1H-pyrrolo[2,3-f]isoquinoline-3-carboxylic acid ethyl ester F1 (0.5 mmol), LiCl (1.49 mmol), Na2CO3.10H2O (1.74 mmol) and (Ph3P)2PdCl2 (0.005 mmol) in EtOH (4 mL) and toluene (4 mL) was heated with microwave irradiation to 150° C. for 20 min. The solvents were removed, DCM was added and the mixture washed with water. The organic layer was dried (Na2SO4), filtered and the solvent evaporated. The crude obtained was purified by chromatography on silica gel (DCM/MeOH 95:5). The title compound was obtained in 50% yield. ESI (+) MS: m/z 243 (MH+). 1H NMR: 1.29 (t, J=7.07, 3H), 2.83-3.00 (m, 4H), 4.20 (q, J=7.07, 2H), 7.42 (d, J=5.00, 1H), 7.59 (d, J=3.17, 1H), 8.29-8.42 (m, 2H), 12.22 (bs, 1H).

Provenance & Evidence