Water → HCID 10138964, compound

Participants

Reaction Steps

The title compound was prepared from 1-(4-methylbenzyl)-5-[4-(trifluoromethoxy)phenyl]-1H-indole and oxalyl chloride in substantially the same manner, as described in Step 3 of Example 25. The product was obtained as a yellow solid, mp: 192-193° C. Mass spectrum (ESI, [M+H]+) m/z 454. 1HNMR (400 MHz, DMSO-d6): δ 13.50 (br s, 1H), 8.70 (s, 1H), 8.42 (s, 1H), 7.77 (d, 2H, J=8.7 Hz), 7.67 (d, 1H, J=8.5 Hz), 7.58 (dd, 1H, J=8.7 Hz and 1.8 Hz), 7.45 (d, 2H, J=8.3 Hz), 7.22 (d, 1H, J=7.9 Hz), 7.15 (d, 2H, J=8.1 Hz), 5.57 (s, 2H), and 2.25 ppm (s, 3H). Elemental Analysis for C25H18F3NO4.0.2 H2O: Calculated: C, 65.70; H, 4.06; N, 3.06. Found: C, 65.74; H, 4.05; N, 2.94.

Provenance & Evidence