4-(Trifluoromethyl)phenylboronic acid → HCID 22032916, compound

Participants

Reaction Steps

The title compound was prepared from 5-bromo-1-butyl-1H-indole (Step 1 of Example 29) and 4-trifluoromethylphenylboronic acid in substantially the same manner, as described in Step 2 of Example 25. The product was obtained as an oil, mp: 52-53° C. Mass spectrum (APCI, [M+H]+) m/z 318. 1HNMR (400 MHz, DMSO-d6): δ 7.91-7.88(m, 3H), 7.76 (d, 2H, J=8.24 Hz), 7.59 (d, 1H, J=8.55 Hz), 7.49 (d, 1H, J=8.56 Hz), 7.43 (d, 1H, J=3.06 Hz), 6.51 (d, 1H, J=3.05 Hz), 4.20 (t, 2H, J=7.01 Hz), 1.74 (p, 2H, J=7.19 Hz), 1.25 (h, 2H, J=7.48 Hz), and 0.88 ppm (t, 3H, J=7.32 Hz). Elemental Analysis for C19H18F3N: Calculated: C, 71.91; H, 5.72; N, 4.41. Found: C, 71.53; H, 5.61; N, 4.36.

Provenance & Evidence