Aluminium lithium hydride → {1-benzyl-5-[4-(trifluoromethoxy)phenyl]-1H-indol-2-yl)methanol

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Reaction Steps

The title compound was prepared from Ethyl 1-benzyl-5-[4-(trifluoromethoxy)phenyl]-1H-indole-2-carboxylate (Step 2 of Example 25) and lithium aluminum hydride in substantially the same manner, as described in Step 1 of Example 21. The product was obtained as a white solid, mp: 108-109° C. Mass spectrum (ESI, [M+H]+) m/z 398. 1HNMR (400 MHz, DMSO-d6): δ 7.82 (s, 1H), 7.76 (d, 2H, J=8.86 Hz), 7.42-7.36 (m, 4H), 7.29 (d, 1H, J=7.03 Hz), 7.27 (d, 1H, J=7.63 Hz), 7.23-7.20 (m, 1H), 7.06 (d, 2H, J=7.03 Hz), 6.52 (s, 1H), 5.50 (s, 2H), 5.36 (t, 1H), and 4.60 ppm (d, 2H). Elemental Analysis for C23H18F3NO2: Calculated: C, 69.52; H. 4.57; N, 3.52. Found: C, 69.21; H, 4.38; N, 3.40.

Provenance & Evidence