Hydrazine hydrate (1:1) → HCID 10114084, compound

Participants

Reaction Steps

The title compound was prepared from {1-(4-methylbenzyl)-5-[4-(trifluoromethoxy) phenyl]-1H-indol-3-yl}(oxo)acetic acid, hydrazine monohydrate and sodium methoxide according to the procedure described in Example 64. The product was obtained as a brown solid, mp: 62-63° C. Mass spectrum (−ESI, [M−H]−) m/z 438. 1HNMR (400 MHz, DMSO-d6): δ 7.79 (s, 1H), 7.75 (d, 2H, J=8.70 Hz), 7.50 (d, 1H, J=8.56 Hz), 7.42-7.39 (m, 4H), 7.12 (d, 2H, J=8.55 Hz), 7.11 (d, 2H, J=8.55 Hz), 5.34 (s, 2H), and 2.23 ppm (s, 3H). Elemental Analysis for C25H20F3NO3: Calculated: C, 68.33; H, 4.59; N, 3.19. Found: C, 68.00; H, 4.59; N, 3.40.

Provenance & Evidence