Aluminium lithium hydride → HCID 59683370, compound

Participants

Reaction Steps

To a room temperature solution of (6-dimethylcarbamoyl-naphthalen-1-ylmethyl)-carbamic acid tert-butyl ester, 8, (20.45 g, 62.4 mmol) in anhydrous THF (300 mL) is added 1 M LAH in THF (125 mL, 2 eq.). After the addition is complete the resulting solution is heated at reflux for 3 hours. The reaction solution is then cooled in an ice bath and quenched by the addition of water (2.7 mL). The resulting mixture is dried over MgSO4. The solid is removed by filtration and the filtrate concentrated in vacuo to afford 14.25 g of the desired product as a colorless oil. LRMS: 229.05 (M+1).

Provenance & Evidence