HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 9841895, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Thiophenecarbonyl chloride | HCID 78928 | — |
| Reactant | 3-(4-Bromo-1-Methyl-1H-Pyrazol-3-Yl)Aniline | HCID 2735391 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 9841895 | HCID 9841895 | 73.6% |
Reaction Steps
To thiophene-2-carbonyl chloride (11 μL, 0.09 mmol) in CH2Cl2 (1 mL) was added dropwise a solution of 3-(3-aminophenyl)4-bromo-1-methylpyrazole (25 mg, 0.09 mmol) and triethylamine (14 μL, 0.09 mmol) in CH2Cl2 (0.5 mL). The reaction mixture was stirred for 16 h and concentrated. Chromatography on flash silica (50% EtOAc/hexane) gave the title compound as a colourless solid (24 mg, 68%), m.p. 127.8-128.6° C. (EtOAc/hexane).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07368539B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-05496deda0f7401bace3fe6e868cfa37 |
| Source note | uspto-grants-2008_05 |