8-Amino-2-iodo-1-methyl-4,5-dihydro-1H-1,7,9-triaza-cyclopenta[a]naphthalene-3-carboxylic acid ethyl ester → HCID 68707164, compound

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Reaction Steps

To a solution of 8-amino-2-iodo-1-methyl-4,5-dihydro-1H-1,7,9-triaza-cyclopenta[a]naphthalene-3-carboxylic acid ethyl ester N1 (1.28 mmol) in 95% EtOH (30 mL) 4M NaOH (1.2 mL) was added. The mixture was heated to reflux for 10 h then cooled and evaporated to dryness. The residue was dissolved in 30 mL of water, acidified with glacial AcOH and the precipitate was filtered and washed with water. The product was dried affording the title compound (95% yield). ESI (+) MS: m/z 371 (MH+). 1H NMR: 2.63 (t, J=7.80, 2H), 2.90 (t, J=7.80, 2H), 4.18 (s, 3H), 6.33 (bs, 2H), 8.00 (s, 1H), 12.26 (bs, 1H).

Provenance & Evidence