Ammonia → HCID 69061410, compound

Participants

Reaction Steps

88 ml of a 25%-strength aqueous ammonia solution was added to a solution of 16 g of the 2-(2,2-dimethyl-1a,7b-dihydro-2H-oxireno[c]chromen-6-yl)-N-1,2,3,4-tetrahydronaphth-1-yl acetamide obtained above in 88 ml ethanol, and the mixture was stirred for 18 hours at room temperature. Then 200 ml dichloromethane and 50 ml methanol were added thereto, and the mixture was stirred for a further 15 minutes. Then 200 ml water was added and the mixture was again stirred for 15 minutes. The organic phase was separated and largely evaporated at reduced pressure. The remaining residue was stirred with 30 ml of ethyl acetate, filtered and dried on a rotary evaporator at 70° C. and 20 bar. 3.1 g 2-(4-amino-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-chromen-6-yl)-N-1,2,3,4-tetrahydronaphth-1-yl acetamide was obtained as grey solid, which was used without further purification for the subsequent reaction.

Provenance & Evidence