Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Pyrrolidone | HCID 12025 | — |
| Reactant | (Chloromethyl)methoxydimethylsilane | HCID 560623 | — |
| Reactant | Potassium cyanate | HCID 11378442 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 69215404 | HCID 69215404 | — |
Reaction Steps
A mixture of 69.3 g of (chloromethyl)methoxydimethyl-silane, 40.6 g of potassium cyanate and 42.6 g of 2-pyrrolidinone in 150 ml of anhydrous DMF was heated at 130° C. with stirring for 5 h. The solvent was then removed under reduced pressure. This gave N-[(methoxydimethylsilyl)methyl]-2-oxo-1-pyrrolidinecarboxamide in quantitative yield with a purity of >90% (analysis by 1H NMR, see Example 2a).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07368586B2 |
|---|
| Source dataset | uspto-grants-2008_05 |
|---|
| ORD ID | ord-40873512c0c041d4b579c07ef7f793aa |
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| Source note | uspto-grants-2008_05 |
|---|
