Hydrogen Bromide → L-Methionine

Participants

Reaction Steps

iPrSH (20 ml) was treated slowly with gaseous HBr. Subsequently L-homoserine (10 mmol) was added and the mixture was stirred for 10 minutes. Thereafter, AlCl3 (40 mmol) was added and the reaction mixture was stirred for 4 h at room temperature. The reaction mixture was quenched using H2O/HCl and then made basic with NaOH. After filtering off Al(OH)3 by suction the filtrate solution was concentrated to dryness and analysed by HPLC. Yield of (1)=8.2%. Activation of L-homoserine at the C-4 atom and reaction to give L-methionine

Provenance & Evidence