HCID 178526897, compound → HCID 178526855, compound

HRID 2221409Notes

Reaction equation

HRID 2221409 reaction equation
[Cl:1][C:2]1[NH:3][C:4](I)=[C:5]([N+:7]([O-:9])=[O:8])[N:6]=1>C(O)C.[OH-].[Pd+2].[OH-].[C]>[Cl:1][C:2]1[NH:3][CH:4]=[C:5]([N+:7]([O-:9])=[O:8])[N:6]=1

Participants

4

Reactant 1

HCID 178526897HCID 178526897, compound

Product 1

HCID 178526855HCID 178526855, compoundYield 83.5%

Reagents, catalysts & solvents 2

HCID 178502593HCID 178502593, compoundCatalystHCID 702EthanolSolvent

Procedure

2-Chloro-5-iodo-4-nitroimidazole (273 mg) was dissolved in ethanol (5 ml), then triethylamine(420 μl) and 20% palladium hydroxide-carbon (27 mg) were added, the reaction mixture was subjected to hydrogenation at a room temperature under normal pressure for 5 hours, there was obtained 2-chloro-4-nitroimidazole (123 mg, yield: 83.4%) as colorless solid product.

Sources & evidence

ORD record
ord-de406dbb2b0e4f9bb448b41be3cb9c66
Source dataset
uspto-grants-2008_05
Patent number
US07368579B2

Reaction notes

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