Hydrochloric Acid → HCID 178512190, compound

Participants

Reaction Steps

The product was prepared starting from 4-[N2,N3-bis(ter-butoxycarbonyl)-N3-(4-fluorobenzyl)-guanidino]-1-aminobutane (116 mg, 0.26 mmol) solubilised in EtOH (1.5 ml). Every 2 hours 1 ml of HCl 12 N was added; after 4 hours, the solution was left for 15 min at room temperature, and then brought to T=55° C. and kept at that temperature for 6 hours. The solution was concentrated at reduced pressure and the residual aqueous phase was washed with CH2Cl2 and AcOEt. The aqueous phase was concentrated to dryness in vacuo, giving 46 mg of product as a yellow oil (yield: 57%). 1H-NMR (CD3OD) δ 7.31-7.24 (2H, m), 7.03-7.12 (2H, m), 4.34 (2H, s), 3.26 (2H, t), 3.17 (2H, t), 1.58-1.53 (2H, m).

Provenance & Evidence