Phthalimide → HCID 53485842, compound

Participants

Reaction Conditions

Reaction Steps

To a reaction vessel were added phthalimide 4.00 g (27.2 mmol), (R)-epichlorohydrin 4.52 g (49.0 mmol), benzyl trimethylammonium chloride 126 mg (0.68 mmol) and isopropanol 25 mL, and the mixture was stirred at 40° C. for 24 hours. To this mixture were dropped a mixture of potassium tert-butoxide 3.66 g (32.6 mmol) and isopropanol 15 mL and the mixture was stirred at 20° C. for 3 hours. After evaporation of the solvent, the condensed residue was dissolved in ethyl acetate and washed with water. The organic layer was taken and recrystallized to give (R)-glycidylphthalimide 4.90 g (Yield 89%, chemical purity 96%) as a white crystal.

Provenance & Evidence