1,2-Dichloroethane → HCID 69139366, compound

Participants

Reaction Steps

To a reaction vessel were added (R)-1-(4-chloro-2-hydroxyphenoxy)-3-phthalimido-2-propanol 348 mg (1.00 mmol), sodium carbonate 159 mg (1.50 mmol) and 1,2-dichloroethane 4 mL. After to the mixture was dropped acetic anhydride 122 mg (1.20 mmol), the mixture was stirred at room temperature for 15 hours. After terminating the reaction by adding water, the water layer was removed and the organic layer was washed with an aqueous 5% HCl solution and an aqueous 5% NaCl solution successively. The organic layer was taken and the solvent was evaporated to give crude (R)-1-(4-chloro-2-acetoxyphenoxy)-3-phthalimido-2-propanol 372 mg (yield 92%, chemical purity 97%) as a pale yellow solid.

Provenance & Evidence