Methanol → HCID 57901185, compound

Participants

Reaction Conditions

Reaction Steps

To a reaction vessel were added crude (R)-1-(4-chloro-2-acetoxyphenoxy)-2-methanesulfonyloxy-3-phthalimidopropane 242 mg (0.50 mmol), sodium carbonate 58.3 mg (0.60 mmol) and methanol 2 mL, and the mixture was stirred at 50° C. for 9 hours. To the reaction mixture was added ethyl acetate and the mixture was washed with water. The solvent was evaporated and recrystallized to give (S)-7-chloro-2-(phthalimidomethyl)-1,4-benzodioxane 114 mg (yield 70%, chemical purity 98%, optical purity 98% ee) as a white solid.

Provenance & Evidence