Hydrochloric Acid → HCID 59710970, compound

Participants

Reaction Steps

To a solution of methyl 2-[4-(N-Boc-aminomethyl)-phenyl]-oxazol-4-ylcarboxylate (1.66 g, 5 mmol) in THF (25 ml)/methanol (25 ml) was added 1M aqueous LiOH (25 ml, 25 mmol). After stirring at room temperature for 3 h, the solution was acidified with 2M aqueous HCl to pH 5-6, and partitioned between ethyl acetate (150 ml) and water (150 ml). The organic layer was washed with brine (150 ml), dried over sodium sulfate and concentrated in vacuo giving the title compound as a white solid (1.58 g, 4.96 mmol).

Provenance & Evidence