Quinaldic Acid → Benzyl Alcohol

Participants

Reaction Steps

The carboxylic acid functionality in the quinolinecarboxylic acid (A) is protected using standard carboxylic acid protection procedures well known in the art, e.g., by formation of the corresponding ester, to give compound (B). For example, the benzyl ester (R21 is benzyl in (B)) may be prepared by treating a solution of compound (A) in EtOAc at room temperature with 1,1′-carbonyldiimidazole to produce the activated, imidazolide derivative of (A, then adding benzyl alcohol to the reaction mixture.

Provenance & Evidence