関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Vanillin | HCID 1183 | — |
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-Chloromethyl-2-(2-furyl)oxazole | HCID 22009706 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-{[2-(2-Furyl)-1,3-oxazol-4-yl]methoxy}-3-methoxybenzaldehyde | HCID 86605705 | 91.4% |
反応手順
A mixture of 4-chloromethyl-2-(2-furyl)-1,3-oxazole (10.0 g), vanillin (8.29 g), potassium carbonate (7.53 g) and N,N-dimethylformamide (100 mL) was stirred at 80° C. for 15 hrs. Water was poured into the reaction mixture, and the precipitated crystals were collected by filtration to give 4-{[2-(2-furyl)-1,3-oxazol-4-yl]methoxy}-3-methoxybenzaldehyde as brown crystals (14.90 g, yield 91%). Recrystallization from hexane-ethyl acetate gave pale-yellow prism crystals. melting point: 138-139° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07368578B2 |
|---|
| 出典データセット | uspto-grants-2008_05 |
|---|
| ORD ID | ord-cd1d1baaf67e444dac7da1ce6a4956ea |
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| 出典メモ | uspto-grants-2008_05 |
|---|
