Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Ethylvanillin | HCID 8467 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-(Chloromethyl)-2-(furan-2-yl)-5-methyl-1,3-oxazole | HCID 22344582 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 85954512 | HCID 85954512 | 69.2% |
Reaction Steps
A mixture of 4-chloromethyl-2-(2-furyl)-5-methyl-1,3-oxazole (30.0 g), 3-ethoxy-4-hydroxybenzaldehyde (22.9 g), potassium carbonate (21.01 g) and N,N-dimethylformamide (300 mL) was stirred at 90° C. for 2 hrs. Water was poured into the reaction mixture, and the precipitated crystals were collected by filtration to give 3-ethoxy-4-[[2-(2-furyl)-5-methyl-1,3-oxazol-4-yl]methoxy]benzaldehyde as brown crystals (31.20 g, yield 69%). Recrystallization from ethyl acetate-hexane gave pale-yellow needle. melting point: 159-160° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07368578B2 |
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| Source dataset | uspto-grants-2008_05 |
|---|
| ORD ID | ord-3c66ffe3fbfd46eda770ec45ac074bd1 |
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| Source note | uspto-grants-2008_05 |
|---|
