Ethanol → HCID 23076452, compound

Participants

Reaction Steps

To a solution of 3-ethoxy-4-[[2-(2-furyl)-5-methyl-1,3-oxazol-4-yl]methoxy]benzaldehyde (20.00 g) in tetrahydrofuran (250 mL)-ethanol (100 mL) was gradually added sodium borohydride (2.31 g) at 0° C. After stirring at room temperature for 1 hr, water was added to the reaction mixture and the precipitated crystals were collected by filtration to give (3-ethoxy-4-{[2-(2-furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}phenyl)methanol as pale-yellow crystals (18.80 g, yield 93%). Recrystallization from ethyl acetate-hexane gave colorless prism crystals. melting point: 141-142° C.

Provenance & Evidence