HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2221512Generated: November 3, 2026
Dimethylformamide → 3-{[2-(2-Furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}-4-methoxybenzaldehyde
https://huagongshe.com/reaction/2221512
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Isovanillin | HCID 12127 | — |
| Reactant | 4-(Chloromethyl)-2-(furan-2-yl)-5-methyl-1,3-oxazole | HCID 22344582 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-{[2-(2-Furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}-4-methoxybenzaldehyde | HCID 86605706 | 67.4% |
Reaction Steps
A mixture of 4-chloromethyl-2-(2-furyl)-5-methyl-1,3-oxazole (20.0 g), 3-hydroxy-4-methoxybenzaldehyde (13.97 g), potassium carbonate (13.96 g) and N,N-dimethylformamide (200 mL) was stirred at 90° C. for 3 hrs. Water was poured into the reaction mixture, and the precipitated crystals were collected by filtration to give 3-{[2-(2-furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}-4-methoxybenzaldehyde as colorless crystals (19.4 g, yield 67%). Recrystallization from ethyl acetate-hexane gave colorless prism crystals. melting point: 125-126° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07368578B2 |
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| Source dataset | uspto-grants-2008_05 |
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| ORD ID | ord-972defa9be714817bab4375ae4205cc1 |
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| Source note | uspto-grants-2008_05 |
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