diethyl (E)-2-(3-benzyloxy-1-phenyl-1H-pyrazol-4-yl)ethenylphosphonate → HCID 178476889, compound

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Reaction Steps

Diethyl (E)-2-(3-benzyloxy-1-phenyl-1H-pyrazol-4-yl)ethenylphosphonate (0.89 g), 5% palladium on carbon (1.0 g) and tetrahydrofuran (50 mL) were subjected to catalytic reduction under a hydrogen atmosphere and atmospheric pressure. The catalyst was filtered off and the filtrate was concentrated to give diethyl 2-(3-hydroxy-1-phenyl-1H-pyrazol-4-yl)ethylphosphonate as colorless crystals (0.54 g, yield 76%). Recrystallization from ethyl acetate-hexane gave colorless prism crystals. melting point: 121-122° C.

Provenance & Evidence