HCID 23076388, compound → HCID 178515970, compound

Participants

Reaction Steps

2-[(E)-2-(3-Benzyloxy-1-phenyl-1H-pyrazol-5-yl)ethenyl]pyridine (2.52 g), 5% palladium on carbon (3.0 g) and tetrahydrofuran (200 mL) were subjected to catalytic reduction under a hydrogen atmosphere and atmospheric pressure. The catalyst was filtered off and the filtrate was concentrated to give 1-phenyl-5-[(E)-2-pyridin-2-ylethenyl]-1H-pyrazol-3-ol as colorless crystals (1.50 g, yield 80%). Recrystallization from ethyl acetate-hexane gave colorless prism crystals. melting point: 167-168° C.

Provenance & Evidence