HCID 23076389, compound → HCID 178469746, compound

Participants

Reaction Steps

Ethyl 3-(pyridin-3-ylmethoxy)-1-(pyridin-3-ylmethyl)-1H-pyrazole-4-carboxylate (1.14 g), 5% palladium on carbon (1.0 g) and tetrahydrofuran (100 mL) were stirred under a hydrogen atmosphere to perform catalytic reduction. After removing palladium on carbon by filtration, the filtrate was concentrated to give ethyl 3-hydroxy-1-(pyridin-3-ylmethyl)-1H-pyrazole-4-carboxylate as colorless crystals (0.62 g, yield 74%). The crystals were recrystallized from ethyl acetate-hexane. melting point: 148-149° C.

Provenance & Evidence