Ethanol → HCID 69214137, compound

Participants

Reaction Steps

To a solution of methyl 2-{4-[(4-formyl-2-methoxyphenoxy)methyl]-5-methyl-1,3-oxazol-2-yl}benzoate (1.30 g) in tetrahydrofuran (20 mL)-ethanol (10 mL) was gradually added sodium borohydride (0.13 g) at room temperature. After stirring for 2 hrs, water was added to the reaction mixture and the precipitated crystals were collected by filtration to give methyl 2-{4-[(4-hydroxymethyl-2-methoxyphenoxy)methyl]-5-methyl-1,3-oxazol-2-yl}benzoate as colorless crystals (1.20 g, yield 92%). Recrystallization from ethyl acetate-hexane gave colorless prism crystals. melting point: 100-101° C.

Provenance & Evidence