Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Vanillin | HCID 1183 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl 4-(4-(chloromethyl)-5-methyloxazol-2-yl)benzoate | HCID 23076573 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 86605714 | HCID 86605714 | 92.5% |
Reaction Steps
A mixture of methyl 4-(4-chloromethyl-5-methyl-1,3-oxazol-2-yl)benzoate (0.80 g), potassium carbonate (0.40 g), vanillin (0.44 g) and N,N-dimethylformamide (30 mL) was stirred at 90° C. for 2 hrs. Water was poured into the reaction mixture, and the precipitated crystals were collected by filtration to give methyl 4-{4-[(4-formyl-2-methoxyphenoxy)methyl]-5-methyl-1,3-oxazol-2-yl}benzoate as colorless crystals (1.02 g, 92%). Recrystallization from tetrahydrofuran-hexane gave colorless prism crystals. melting point: 185-186° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07368578B2 |
|---|
| Source dataset | uspto-grants-2008_05 |
|---|
| ORD ID | ord-32aee28e3e6f4f5f8b207d5d043cd27f |
|---|
| Source note | uspto-grants-2008_05 |
|---|
