Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Vanillin | HCID 1183 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Thiazole, 4-(chloromethyl)-5-methyl-2-phenyl- | HCID 12794636 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 86605715 | HCID 86605715 | 92.5% |
Reaction Steps
A mixture of 4-chloromethyl-5-methyl-2-phenyl-1,3-thiazole (1.0 g), potassium carbonate (0.57 g), vanillin (0.62 g) and N,N-dimethylformamide (30 mL) was stirred at 90° C. for 2 hrs. Water was poured into the reaction mixture, and the precipitated crystals were collected by filtration to give 3-methoxy-4-[(5-methyl-2-phenyl-1,3-thiazol-4-yl)methoxy]benzaldehyde as colorless crystals (1.28 g, 92%). Recrystallization from ethyl acetate-hexane gave colorless prism crystals. melting point: 133-134° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07368578B2 |
|---|
| Source dataset | uspto-grants-2008_05 |
|---|
| ORD ID | ord-d9793bf33a8443c2b6722bfe4574b6d2 |
|---|
| Source note | uspto-grants-2008_05 |
|---|
