Ethanol → HCID 69216948, compound

Participants

Reaction Steps

To a solution of 3-methoxy-4-[(4-methyl-2-phenyl-1,3-thiazol-5-yl)methoxy]benzaldehyde (2.80 g) in tetrahydrofuran (50 mL)-ethanol (10 mL) was gradually added sodium borohydride (0.31 g) at room temperature. After stirring the reaction mixture at room temperature for 2 hrs, water was added, and the precipitated crystals were collected by filtration to give {3-methoxy-4-[(4-methyl-2-phenyl-1,3-thiazol-5-yl)methoxy]phenyl}methanol as colorless crystals (2.57 g, yield 92%). Recrystallization from ethyl acetate-hexane gave colorless prism crystals. melting point: 152-153° C.

Provenance & Evidence