Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Vanillin | HCID 1183 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 23076531 | HCID 23076531 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 86605742 | HCID 86605742 | 86.1% |
Reaction Steps
A mixture of 3-(4-chloromethyl-5-methyl-1,3-oxazol-2-yl)benzonitrile (26.3 g), vanillin (17.19 g), anhydrous potassium carbonate (15.62 g) and N,N-dimethylformamide (300 mL) was stirred at 90° C. for 2 hrs. Water was poured into the reaction mixture, and the precipitated crystals were collected by filtration to give 3-{4-[(4-formyl-2-methoxyphenoxy)methyl]-5-methyl-1,3-oxazol-2-yl}benzonitrile as colorless crystals (33.9 g, yield 86%). Recrystallization from ethyl acetate-hexane gave colorless prism crystals. melting point: 166-167° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07368578B2 |
|---|
| Source dataset | uspto-grants-2008_05 |
|---|
| ORD ID | ord-7e76cf3c176c44b68b6983377071cef4 |
|---|
| Source note | uspto-grants-2008_05 |
|---|
