HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → [(1-ethyl-1H-imidazol-5-yl)methyl](triphenyl)phosphonium chloride hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 5-(Chloromethyl)-1-Ethyl-1H-Imidazole Hydrochloride | HCID 22938740 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | [(1-ethyl-1H-imidazol-5-yl)methyl](triphenyl)phosphonium chloride hydrochloride | HCID 86605744 | 72% |
Reaction Steps
5-Chloromethyl-1-ethyl-1H-imidazole hydrochloride (6.00 g), triphenylphosphine (25.73 g) and acetonitrile (80 mL) were heated under reflux overnight. After cooling, the precipitated crystals were collected by filtration and washed with hexane to give [(1-ethyl-1H-imidazol-5-yl)methyl](triphenyl)phosphonium chloride hydrochloride as colorless crystals (10.50 g, yield 72%). melting point: 287-289° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07368578B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-5b0c2ca112e24f53b51f9378c49f9e92 |
| Source note | uspto-grants-2008_05 |