HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 4-(Chloromethyl)-1-ethyl-1H-pyrazole hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (1-ethyl-1H-pyrazol-4-yl)methanol | HCID 4711794 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(Chloromethyl)-1-ethyl-1H-pyrazole hydrochloride | HCID 23076562 | 100.2% |
Reaction Steps
To a solution (400 mL) of (1-ethyl-1H-pyrazol-4-yl)methanol (16.80 g) in tetrahydrofuran was added thionyl chloride (40.0 g), and the mixture was stirred at room temperature for 4 hr. The mixture liquid was concentrated under reduced pressure to obtain 4-chloromethyl-1-ethyl-1H-pyrazole hydrochloride as a colorless oil (24.15 g, yield 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07368578B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-96222216876340cda1bf30403b692e93 |
| Source note | uspto-grants-2008_05 |