HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → Diethyl [(2-isopropyl-1,3-oxazol-4-yl)methyl]phosphonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Triethyl phosphite | HCID 31215 | — |
| Reactant | 4-(Chloromethyl)-2-(propan-2-yl)-1,3-oxazole | HCID 2763291 | — |
| Solvent | Ethanol ethylacetate | HCID 21584252 | — |
| Product | Diethyl [(2-isopropyl-1,3-oxazol-4-yl)methyl]phosphonate | HCID 85954640 | 91.1% |
Reaction Conditions
| Temperature | 160 °C |
|---|
Reaction Steps
A mixture of 4-chloromethyl-2-isopropyl-1,3-oxazole (1.12 g) and triethyl phosphite (2.57 g) was stirred at 160° C. for 16 hrs. Excess triethyl phosphite was evaporated under reduced pressure. The residue was subjected to silica gel column chromatography and eluted with ethyl acetate-hexane (1:1, v/v), ethyl acetate, then ethyl acetate-ethanol (10:1, v/v) to give diethyl [(2-isopropyl-1,3-oxazol-4-yl)methyl]phosphonate as a colorless oil (1.67 g, yield 91%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07368578B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-7eb9572b077c467895cf414ba5893ee3 |
| Source note | uspto-grants-2008_05 |