反应详情

温度

160 °C

A mixture of 2-tert-butyl-4-chloromethyl-1,3-thiazole (8.66 g) and triethyl phosphite (15.7 g) was stirred at 160° C. for 20 hrs. Excess triethyl phosphite was evaporated under reduced pressure. The residue was subjected to silica gel column chromatography and eluted with ethyl acetate-hexane (1:2 to 1:0, v/v) to give diethyl [(2-tert-butyl-1,3-thiazol-4-yl)methyl]phosphonate as a colorless oil (12.0 g, yield 90%).

1. customExcess triethyl phosphite was evaporated under reduced pressure
2. washeluted with ethyl acetate-hexane (1:2 to 1:0